How do you extract vincristine/vinblastine from the Madagscar Periwinkle?

There are used several methods:


Supercritical Fluid Extraction ( yield about 76% )


http://www.jstage.jst.go.jp/article/cpb/...





Use of an organ culture:


http://www.freepatentsonline.com/4831133...


http://www.actahort.org/books/447/447_29...





Extraction with solvent combined with semi-synthetic ( enzymatic ) production process:


http://209.85.135.104/search?q=cache:qHd...


http://www.freepatentsonline.com/4918011...


http://www3.interscience.wiley.com/cgi-b...

How do you extract vincristine/vinblastine from the Madagscar Periwinkle?
ten enzymatic steps...http://rds.yahoo.com/_ylt=A0geu4_htMtHW3...